Description
We are proud to offer BPC-157 as either 5mg of powder or a spray bottle containing 2mg with 20mcg per spray.
BPC-157 (Body Protection Compound-157) is a synthetic peptide consisting of 15 amino acids. It has gained considerable attention in recent years for its potential therapeutic effects on various physiological processes. BPC-157 has been extensively studied for its tissue healing and regenerative properties, along with its anti-inflammatory and cytoprotective actions. This article provides an overview of the mechanism of action of BPC-157 and summarizes the key findings from in vitro and in vivo studies.
Mechanism of Action:
The precise mechanism of action of BPC-157 is not yet fully understood, but it is believed to involve multiple pathways and cellular processes. BPC-157 exhibits a high affinity for receptors in the gastrointestinal (GI) tract, which suggests its involvement in gut-related activities. Moreover, it has been shown to interact with several growth factors and modulate the expression of various genes involved in tissue repair, angiogenesis, and inflammation [1].
In Vitro Studies:
In vitro studies have provided valuable insights into the cellular mechanisms underlying the therapeutic effects of BPC-157. These studies have demonstrated that BPC-157 promotes cell survival and proliferation, stimulates extracellular matrix formation, and enhances angiogenesis [2]. Furthermore, BPC-157 has shown anti-inflammatory properties by inhibiting the production of pro-inflammatory cytokines and promoting the release of anti-inflammatory factors. It has also been found to protect cells from oxidative stress-induced damage and apoptosis. These in vitro findings highlight the potential of BPC-157 as a promising therapeutic agent for tissue repair and regeneration.
In Vivo Studies:
Numerous animal studies have been conducted to evaluate the in vivo effects of BPC-157. These studies have explored its efficacy in various models of tissue injury, inflammation, and organ damage. BPC-157 has consistently demonstrated beneficial effects in accelerating wound healing, reducing inflammation, and protecting against organ damage. It has been shown to enhance the healing of tendons, ligaments, muscles, and bones. Moreover, BPC-157 has exhibited neuroprotective effects by improving outcomes in animal models of traumatic brain injury and spinal cord injury [3]. Additionally, it has shown potential in ameliorating gastrointestinal disorders such as ulcerative colitis and gastric ulcers.
BPC-157 and Angiogenesis:
Angiogenesis, the formation of new blood vessels, is a critical process in tissue repair and regeneration. BPC-157 has been found to promote angiogenesis, which contributes to its healing properties. Animal studies have shown that BPC-157 enhances blood vessel formation in injured tissues and improves blood flow, thereby facilitating the delivery of oxygen and nutrients to promote healing.
BPC-157 and Inflammation:
Inflammation is a complex physiological response that plays a crucial role in tissue repair but, when excessive or prolonged, can contribute to tissue damage and chronic conditions. BPC-157 has demonstrated potent anti-inflammatory effects by reducing the production of pro-inflammatory mediators and promoting the release of anti-inflammatory factors. These actions help regulate the inflammatory response and prevent excessive tissue damage, facilitating the healing process [4].
Safety and Side Effects:
Overall, BPC-157 has exhibited a favorable safety profile in various animal studies. It has shown no significant toxicity or adverse effects at therapeutic doses. However, further research is necessary to determine the long-term safety and potential side effects in humans.
Conclusion:
BPC-157 is a promising peptide with potent regenerative, anti-inflammatory, and cytoprotective properties. In vitro and in vivo studies have demonstrated its ability to enhance tissue healing, promote angiogenesis, and reduce inflammation. Although the precise mechanism of action remains to be fully elucidated, BPC-157’s effects involve modulating various cellular pathways and growth factors.
Warning: NEWSARMS PRODUCTS ARE INTENDED AS A RESEARCH CHEMICAL ONLY. Bodily introduction of any kind into humans or animals is strictly forbidden by law.
- Seiwerth S, Milavic M, Vukojevic J, et al. Stable Gastric Pentadecapeptide BPC 157 and Wound Healing. Front Pharmacol. 2021;12:627533. Published 2021 Jun 29. doi:10.3389/fphar.2021.627533
- Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985). 2011;110(3):774-780. doi:10.1152/japplphysiol.00945.2010
- Sikiric P, Seiwerth S, Rucman R, et al. Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications. Curr Neuropharmacol. 2016;14(8):857-865. doi:10.2174/1570159×13666160502153022
- Keremi B, Lohinai Z, Komora P, et al. Antiinflammatory effect of BPC 157 on experimental periodontitis in rats. J Physiol Pharmacol. 2009;60 Suppl 7:115-122.
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