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We are proud to sell Epitalon in a 10ml nasal spray with 10mg per bottle, and 100mcg per spray, and as a powder with 50mg per bottle.

Epitalon, also known as Epithalon or Epithalamin, is a synthetic peptide with potential anti-aging and rejuvenating properties. It has gained attention for its ability to stimulate the production of telomerase, an enzyme involved in maintaining the length of telomeres, the protective caps at the ends of chromosomes. This article provides an overview of the mechanism of action of Epitalon and summarizes key findings from in vitro and in vivo studies.

Mechanism of Action:

Epitalon acts through multiple mechanisms to exert its effects on cellular aging and rejuvenation. One of its primary actions is the upregulation of telomerase activity. Telomerase is an enzyme responsible for adding nucleotide repeats to the ends of chromosomes, which helps maintain telomere length. Telomeres naturally shorten with each cell division, and their shortening is associated with cellular senescence and aging. By increasing telomerase activity, Epitalon helps slow down telomere shortening and potentially delays the aging process.Furthermore, Epitalon has been found to stimulate the pineal gland’s production of melatonin, a hormone involved in regulating sleep patterns, antioxidant activity, and overall well-being. Melatonin is known for its antioxidant properties and its ability to scavenge free radicals, which can contribute to cellular damage and aging [1].

In Vitro Studies:

In vitro studies have provided valuable insights into the cellular mechanisms underlying the effects of Epitalon. These studies have shown that Epitalon can increase telomerase activity in various cell types, including human embryonic cells, fibroblasts, and lymphocytes. By activating telomerase, Epitalon helps preserve telomere length and potentially promotes cellular longevity. Epitalon has also demonstrated antioxidant effects in vitro. It has been shown to reduce oxidative stress, protect cells from DNA damage, and enhance the activity of antioxidant enzymes. These findings suggest that Epitalon’s anti-aging effects may be attributed, at least in part, to its ability to counteract oxidative stress and reduce cellular damage [2].

In Vivo Studies:

Animal studies have been conducted to evaluate the in vivo effects of Epitalon on aging and age-related conditions. These studies have shown promising results.In models of accelerated aging, Epitalon has been found to extend the lifespan of experimental animals. It has also been shown to improve various markers of aging, including overall health, reproductive function, immune response, and cognitive function. Epitalon’s ability to delay or reverse age-related changes suggests its potential as an anti-aging intervention.

Additionally, Epitalon has shown positive effects on the endocrine system. It has been found to restore normal hormone levels, including melatonin, growth hormone, and reproductive hormones. These effects contribute to the overall rejuvenating properties of Epitalon [3].

Epitalon and Cancer:

Epitalon has also been studied for its potential anticancer properties. Research has indicated that Epitalon can inhibit the growth of cancer cells, induce apoptosis (programmed cell death), and reduce tumor formation. It has also been found to enhance the effectiveness of certain chemotherapy drugs. However, further research is needed to fully understand Epitalon’s anticancer mechanisms and its potential clinical applications [4].

Safety and Side Effects:

Epitalon has generally shown a good safety profile in preclinical and clinical studies. It is well-tolerated, with minimal reported side effects. However, as with any compound, individual responses may vary, and it is advisable to consult with healthcare professionals before use, especially for individuals with pre-existing medical conditions or those taking other medications [5].


Epitalon, a synthetic peptide, shows promise as a potential anti-aging and rejuvenating agent through its mechanisms of action. By upregulating telomerase activity, Epitalon helps preserve telomere length and potentially delays the aging process. It also stimulates melatonin production, which contributes to its antioxidant and overall well-being effects.In vitro studies have demonstrated Epitalon’s ability to increase telomerase activity and reduce oxidative stress. Animal studies have further supported its anti-aging effects by extending lifespan, improving markers of aging, and restoring hormone levels. Additionally, Epitalon has shown potential as an anticancer agent by inhibiting tumor growth and enhancing the efficacy of chemotherapy drugs.

While Epitalon has shown a good safety profile, further research is needed to establish its long-term safety, optimal dosages, and potential interactions with other medications. Consulting with healthcare professionals is crucial before considering the use of Epitalon.

Overall, Epitalon offers exciting possibilities in the field of anti-aging research. However, more research is necessary to fully understand its mechanisms of action and to explore its potential benefits and applications in humans.

WARNING This product is intended for research purposes only. The research chemical designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

  1. Khavinson V, Diomede F, Mironova E, et al. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules. 2020;25(3):609. Published 2020 Jan 30. doi:10.3390/molecules25030609
  2. Yue X, Liu SL, Guo JN, et al. Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitroAging (Albany NY). 2022;14(7):3191-3202. doi:10.18632/aging.204007
  3. Khavinson VK, Izmaylov DM, Obukhova LK, Malinin VV. Effect of epitalon on the lifespan increase in Drosophila melanogaster. Mech Ageing Dev. 2000;120(1-3):141-149. doi:10.1016/s0047-6374(00)00217-7
  4. Kossoy G, Zandbank J, Tendler E, et al. Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa. Int J Mol Med. 2003;12(4):473-477.
  5. Anisimov VN, Khavinson VKh, Popovich IG, et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4):193-202. doi:10.1023/a:1025114230714

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Powder (50mg), Nasal Spray (10mg)

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