The ingredients in TEST-UP purchased separately cost over $300 a month. With TEST-UP the blend is formulated to boost your natural production of test while acting as a mild aromatase inhibitor. All the ingredients in this product are backed by clinical studies to support their effectiveness-In studies of men eligible for TRT (having low testosterone) taking the ingredients in TEST-UP proved to boost testosterone levels by up to 365% while lowering estrogen by 35%. TEST-UP was formulated for the specific purpose of stimulating the production of testosterone, especially for those who have been on PEDs that may slow or stop production all together.
BULBINE NATALENSIS 10:1
Aqueous extract of Bulbine natalensis Baker (Asphodelaceae) stem at 25, 50 and 100 mg/kg body weight was investigated for anabolic and androgenic effects in male Wistar rats. Sixty male rats were grouped into four (A-D) consisting of 15 each. Group A (control) was orally treated with 0.5 mL of distilled water for 14 days while groups B, C and D were treated like the control except they received 0.5 mL containing 25, 50, and 100 mg/kg body weight of the extract respectively. All the doses of the extract increased (P <0.05) the testicular-body weight ratio as well as alkaline phosphatase activity, glycogen, sialic acid, protein, and cholesterol content of the testes except the single administration of 100 mg/kg body weight which compared well (P>0.05) with the controls for glycogen and cholesterol. The testicular and serum testosterone concentration were increased except in the 100 mg/kg body weight where the effect on the tissue and serum hormone did not manifest until after the first and seven daily doses respectively. Testicular acid phosphatase activity, serum follicle stimulating and luteinizing hormone concentrations also increased at all the doses except in the 100 mg/kg body weight where the effect on the enzyme and the hormone did not manifest until after seven days. The increases were most pronounced in the 50 mg/kg body weight extract treated animals. The results indicate anabolic and androgenic activities of Bulbine natalensis stem in male rat testes with the 50 mg/kg body weight of the extract exhibiting the highest anabolizing and androgenic acti vities. These activities further support the folkloric use of the plant most especially at 50 mg/kg body weight in the management of male sexual dysfunction in South Africa.
The effects of oral administration of aqueous extract of Bulbine natalensis Baker stem at daily doses of 25, 50, and 100 mg/kg body weight on the reproductive function of Wistar rats were evaluated. The indices of mating and fertility success as well as quantal frequency increased after 7 days of treatment in all the dose groups except the 100 mg/kg body weight group. The number of litters was not statistically different (P > 0.05) from the control. Whereas the absolute weights of the epididymis, seminal vesicle, and prostate were not affected, that of the testes was significantly increased. The epididymal sperm count, motility, morphology, and viscosity were not different from the control after 7 days of treatment. The male rat serum testosterone, progesterone, luteinizing hormone, and follicle-stimulating hormone significantly increased in the 25 and 50 mg/kg body weight groups, whereas the estradiol concentration decreased significantly at all the doses. The extract dose of 100 mg/kg body weight decreased the serum testosterone and progesterone levels in male rats. The prolactin concentration was not affected by all the doses. All the indices of reproduction, maternal, embryo/fetotoxic, teratogenic, and reproductive hormones in the female rats were not statistically different from that of their control except the resorption index, which increased at the dose of 100 mg/kg body weight of the extract. Histologic examination of the cross section of rat testes that received the extract at all the doses investigated revealed well-preserved seminiferous tubules with normal amount of stroma, normal population of spermatogenic and supporting cells, as well as normal spermatocytes within the lumen. The results revealed that the aqueous extract of Bulbine natalensis stem at doses of 25 and 50 mg/kg body weight enhanced the success rate of mating and fertility due to increased libido as well as the levels of reproductive hormones in male rats. The absence of alterations in the reproductive parameters of female rats at doses of 25 and 50 mg/kg body weight of Bulbine natalensis stem extract suggest that the extract is “safe” for use at these doses by females during the organogenic period of pregnancy, whereas the extract dose of 100 mg/kg body weight portends a negative effect on some reproductive functions of male and female rats.
Effect of Bulbine natalensis Baker Stem Extract on the Functional Indices and Histology of the Liver and Kidney of Male Wistar Rats
The effects of aqueous extract of Bulbine natalensis Baker stem at 25, 50, and 100 mg/kg of body weight for 14 days on the functional indices of liver and kidney as well as the histology of the rat organs were evaluated. The extract did not significantly (P < .05) alter the total protein, sodium, potassium, chloride, calcium, magnesium, uric acid, and creatinine levels in the serum of rats. However, the 50 and 100 mg/kg of body weight doses reduced the liver- and kidney-body weight ratios by the end of the experimental period. While the extract increased the activities of liver γ-glutamyl transferase (GGT), alkaline phosphatase (ALP), alanine and aspartate aminotransferase (ALT and AST, respectively), and total bilirubin, globulin, and urea, the levels of albumin, conjugated bilirubin, inorganic phosphorus, and kidney ALP and GGT decreased. The activities of serum ALP, GGT, ALT, and AST also increased throughout the experimental period. The extract produced higher effects on the liver functional indices (39%) than the kidney parameters (21%). Histological examination revealed slight distortions in the architecture of the liver lobules as well as proximal and convoluted tubules of the kidney. The alterations produced in some of the functional indices as well as in the hepatorenal architecture may adversely affect the normal hepatic and renal functions. The parameter-specific effect of the extract suggests selective toxicity. This is an indication that the extract is not completely “safe” as an oral remedy.
Treatment of post operative scars with a tape containing a gel from Bulbine frutescens
Postoperative scars are treated by a method of applying a microporous paper tape to the scar running along the length of the scar. A contact medium is applied to the exposed surface of the tape and penetrates to the skin. The contact medium comprises an expressed gel from the plant Bulbine frutescens and may contain asiaticoside and panthenol. These active ingedients are contained in a pharmaceutically acceptable cream. The contact material is applied each morning and evening. The tape is replaced when it falls away from the skin normally, e.g. every seven days and the treatment is then continued. Improved scar healing results from the use of this method.
The rhizomes of Bulbine natalensis furnished six previously unreported anthraquinone derivatives (1–6), together with eight known specialized metabolites. Their structures were determined by interpretation of 1D and 2D NMR and HRESIMS data. The absolute configurations of compounds 1–6 were determined by specific rotation and circular dichroism experiments. The isolated compounds were evaluated for antimicrobial activities, and compound 1 was found to be a moderate inhibitor (IC50 0.02 μM) against methicillin-resistant Staphylococcus aureus (MRSA).
The clinical efficacy and acceptance of L-arginina HCL was tested in 40 infertile men. All of these men had a normal number of spermatozoa (> 20 million/ml), but a decreased motility; this decreased motility was not due to infection or to immunological disorders. The treatment consisted of 80 ml of 10% L-arginine HCL administered daily per os for 6 months. L-arginine HCL showed to be able to improve the motility of spermatozoa without any side-effects.
Rat studies investigating how bulbine natalensis interacts with testosterone note that 50mg/kg (of a 10:1 extraction) appear to be the optimal dosage, and based on Body Surface Area Conversions, this correlates into an estimated human dose of 8mg/kg or:
⦁ 550mg for a 150lb person
⦁ 730mg for a 200lb person 2-3 caps
⦁ 900mg for a 250lb person 3-4 caps
These doses are currently only estimates, but they are within the range seen in the only industry funded trial on bulbine natalensis at this moment in time (which used 650mg). Doses would be 10-fold higher if the raw plant is used without any particular extraction.
In a randomized, double-blind, placebo-controlled, multicenter study of 200 men with benign prostate enlargement, half the group received 180 mg of beta-sitosterol daily while the other half received placebo. After six months, the beta-sitosterol group saw improvement in the International Prostate Symptom Score, the measurement of urine flow (Qmax), and the amount of residual urine remaining in the bladder (PVR).’ The beta-sitosterol group showed a 7.4-point decrease in the International Prostate Symptom Score, compared to a decrease of only 2.1 points in the placebo group. This was a significant 3.5-foId improvement in the men taking beta-sitosterol
Beta-Sitosterol and Prostate Cancer A study using the prostate cancer cell line LNCaP (an androgen dependent tumor) showed that beta-sitosterol decreased cancer cell growth by 24% and induced apoptosis (programmed cell death) four-fold. These findings were correlated with a 50% increase in ceramide production.” Research suggests that ceramide, an important component of the cell membrane, induces apopotosis.’ Growth of the human prostate cancer PC-3 cell line (androgen independent) implanted in mice was compared in two groups receiving either a 2% phytosterol mixture or a cholesterol mixture. In the in vitro studies, both beta-sitosterol and campesterol inhibited the growth of PC-3 cells by 70% and 14%, respectively. Cholesterol supplementation, by contrast, increased the growth by 18% when compared with controls.” Phytosterols inhibited the invasion of PC-3 celis into Matrigel-coated membranes by 78% (a measure of cancer invasiveness), while cholesterol increased it by 43% compared to the cells in the control media.” Migration of tumor celis through 8-micron pore membranes (a measure of tumor motility) was reduced by 60-93% when the PC-3 cells were in phytosterol media, compared to a 67% increase after cholesterol supplementation.^
Cell Line Phytosterol Product Cell Growth Apoptosis Tumor Size Other Findings Reference MDA-MB231 human breast cancer MDA-MB231 human breast cancer PC-3 human prostate cancer LNCaP human prostate cancer HT-29 human colon cancer beta-sitostero! and campesteroi beta-sitosterol 2% phytosterol mixture beta sitosterol beta-sitosterol 80% 6-fold 33% Metastases to lungs and nodes 4-20% 70% 70% 40-43% 4-fold •G2M phase cell cycle arrest • Inhibition of basement membrane invasion Metastases to lungs and nodes 4.-50% ^Ceramide production 50% FCeramide production ^•membrane cholesterol 26% 12,13 14 10 16,17 Table 2: Tumor Cell Lines and Effects of Phytosterols. Breast, prostate, and colon cancer cell lines showed significant decreases
Departments of Biochemistry, Urology, and Obstetrics and Gynecology, C.S.M. Medical University, Lucknow, India.
Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening.
High-performance liquid chromatography assay for quantitation of dopa, adrenaline, and noradrenaline in seminal plasma and blood. Estimation by RIA of hormonal parameters in blood plasma, namely T, LH, FSH, and PRL.
Main Outcome Measure(s)
Before and after treatment, serum T, LH, FSH, PRL, dopamine, adrenaline, and noradrenaline in seminal and blood plasma were measured.
Decreased sperm count and motility were seen in infertile subjects. Serum T and LH levels, as well as seminal plasma and blood levels of dopamine, adrenaline, and noradrenaline were also decreased in all groups of infertile men. This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects. Treatment with M. pruriens significantly improved T, LH, dopamine, adrenaline, and noradrenaline levels in infertile men and reduced levels of FSH and PRL. Sperm count and motility were significantly recovered in infertile men after treatment.
Treatment with M. pruriens regulates steroidogenesis and improves semen quality in infertile men.
⦁ Help control diabetes
People with diabetes are often recommended to include fenugreek seeds in their diet because of the positive effects they can have on their health. Studies conducted on the effect of fenugreek seeds on type 2 diabetes have produced favorable results. It was found that fenugreek seeds help control blood sugar and decrease insulin resistance.
0. Improve breast milk production
Fenugreek seeds have been used by women to increase their breast milk production across Asia. The herb contains phytoestrogen that boosts milk production in lactating mothers. Drinking fenugreek tea seems to increase the supply of breast milk in mothers, which promotes weight gain in infants.
0. Alleviate menstrual cramps
Fenugreek seeds can also help in reducing the pain of menstrual cramps as well as other symptoms associated with menstruation. Fenugreek seeds have anti-inflammatory and analgesic properties, which is why studies sought to investigate the effect they might have on the pain caused by menstruation. It was found that fenugreek seed powder substantially reduced the pain and symptoms such as fatigue, headache, and nausea.
0. Prevent heart attacks
Fenugreek seeds have a significant effect on cardiovascular health. It protects the heart from serious damage during a heart attack. Heart attacks are a major cause of death, and they occur when an artery leading to the heart gets clogged. Fenugreek seeds prevent further damage to the heart and counteract the oxidative stress that occurs during a heart attack.
0. Reduce cholesterol
Studies have proven that fenugreek seeds help to lower the cholesterol level, especially the ‘bad’ cholesterol or LDL in our body. Fenugreek seeds have a flavonoid named naringenin that lowers the lipid levels in those with high cholesterol.
0. Aid digestion
For those suffering from stomach ailments, fenugreek can be a boon. It is an effective treatment for gastritis and indigestion. It aids in preventing constipation as well as digestive problems created by stomach ulcers. This is because it is a natural digestive tonic, and its lubricating properties help soothe your stomach and intestines.
0. Help in weight loss
If you want to lose weight, adding fenugreek seeds to your diet is a must. Fenugreek seeds help in preventing the accumulation of fat and improve the metabolism of lipids and glucose that help in weight loss.
0. Protect liver
Your liver cleanses your body of toxins. An injury to the liver can have a serious impact on your health. One of the main causes of decreased liver function is excessive alcohol intake, and studies have shown that fenugreek seeds are very effective in controlling the impact of alcohol on your liver. Fenugreek seeds protect the liver from alcohol toxicity. Excessive alcohol intake can cause chronic liver damage. Fenugreek seeds contain polyphenolic compounds that help in reduce liver damage and help metabolize the alcohol.
2 Month Supply | 120 Capsules
Serving Size: 2 capsules
Servings per container: 60
120 caps per bottle
Vitamin D3 (cholecalciferol) 250 IU 42%
Vitamin B 6 (Pyrodoxine Hcl) 12.5 mg 750%
Magnesium as AAC 7.5 mg 2%
Zinc (citrate) 2.5 mg 15%
TOTAL MG PER CAP 837.5mg
Other ingredients: Gelatin – see next panel for Blend.
Bulbine Natalensis 10:1 200MG; L Arginine HCL 100MG; Fenugreek seeds 100MG; Orchic Substance 50MMG; Milk thistle 80% silymarin 50MG; 3-4-divanillyltetrahydrofuran-divanil 50MG; Suprarenal Cortex Substance 50MG; Mucuna Pruriens 50MG; Basella Alba 25:1 50MG; Saffron 25MG;; Methyltheobromine 20MG; Beta Sitosterol 25MG; Acetyl-L-Carnitine 25mg