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LGD 4

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SKU: LGD4 Category: Tag:
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Description

We are proud to offer LGD4 in a bottle of 90 capsules with 5mg per capsule.

LGD-4 is a selective androgen receptor modulator (SARM) that has gained significant attention for its potential anabolic effects on muscle and bone tissues. It is widely studied for its ability to promote muscle growth and improve physical performance without the unwanted androgenic side effects associated with traditional anabolic steroids. This article provides an overview of the mechanism of action of LGD4 and summarizes key findings from in vitro and in vivo studies.

Mechanism of Action:

LGD4 selectively binds to androgen receptors in skeletal muscle and bone tissues, leading to its anabolic effects. It exhibits tissue-selective activity, which means it primarily affects the desired tissues while minimizing side effects in other organs.

Upon binding to androgen receptors, LGD4 initiates a cascade of molecular events that promote protein synthesis, muscle fiber hypertrophy, and increased muscle strength. It activates androgen receptor signaling pathways, which are responsible for regulating gene expression involved in muscle growth and repair.

LGD4’s tissue-selective activity allows it to target skeletal muscle tissue specifically, leading to anabolic effects while minimizing adverse effects on other tissues, such as the prostate or sebaceous glands [1].

In Vitro Studies:

In vitro studies have provided valuable insights into the cellular mechanisms underlying the effects of LGD4. These studies have demonstrated that LGD4 promotes protein synthesis in muscle cells, leading to increased muscle mass and hypertrophy. It has also been shown to enhance muscle cell differentiation, which is crucial for muscle repair and growth.

Moreover, LGD4 has been found to stimulate the proliferation and differentiation of satellite cells, which are responsible for muscle regeneration and repair. This suggests that LGD4 may have potential therapeutic applications for muscle wasting conditions or muscle injuries [2].

In Vivo Studies:

Animal studies have been conducted to evaluate the in vivo effects of LGD4 on muscle mass, strength, and physical performance. These studies consistently demonstrate LGD4’s anabolic properties without the androgenic side effects associated with traditional anabolic steroids.

In models of muscle wasting conditions, LGD4 has shown the ability to prevent muscle loss and increase lean body mass. It has also been observed to improve muscle strength and function, suggesting its potential as a therapeutic agent for muscle-related disorders [3].

Additionally, LGD4 has been investigated for its effects on bone health. Animal studies have shown that LGD4 increases bone mineral density and improves bone strength. This may be attributed to its ability to enhance osteoblastic activity, which promotes bone formation, while suppressing osteoclastogenesis, the process of bone resorption [4].

LGD4 and Performance Enhancement:

LGD4 has gained popularity among athletes and fitness enthusiasts due to its potential to enhance physical performance and muscle development. Animal studies have shown that LGD4 improves exercise performance, endurance, and recovery.

In animal models subjected to exercise training, LGD4 has been found to increase running endurance and improve grip strength. These findings suggest that LGD4 may have ergogenic effects, making it an attractive option for athletes and individuals looking to improve their physical performance [5].

Safety and Side Effects:

LGD4 has generally shown a good safety profile in preclinical and clinical studies. However, it is important to note that prolonged use or high doses of LGD4 may lead to potential side effects. Some studies have reported mild suppression of natural testosterone production [6].

Additionally, more research is needed to establish the long-term safety profile of LGD4, especially regarding its effects on hormonal balance and potential interactions with other medications or supplements.

Conclusion:

LGD4 is a selective androgen receptor modulator (SARM) that has shown promise in promoting muscle growth, improving physical performance, and enhancing bone health. It selectively targets and binds to androgen receptors in skeletal muscle and bone tissues, leading to increased protein synthesis, muscle fiber hypertrophy, and improved muscle strength.

In vitro studies have demonstrated LGD4’s ability to stimulate protein synthesis, promote muscle cell differentiation, and enhance satellite cell proliferation. These findings suggest its potential therapeutic applications for muscle wasting conditions and muscle injuries.

Animal studies have consistently shown LGD4’s anabolic effects, including the prevention of muscle loss, increased lean body mass, and improved muscle strength and function. Furthermore, LGD4 has demonstrated positive effects on bone health, including increased bone mineral density and improved bone strength.

LGD4 has also shown potential as an ergogenic aid, enhancing exercise performance, endurance, and recovery. Its ability to improve running endurance, grip strength, and overall physical performance makes it an attractive option for athletes and individuals seeking performance enhancement.

While LGD4 has generally exhibited a good safety profile, it is important to be aware of potential side effects, such as mild suppression of natural testosterone production. Careful monitoring and proper post-cycle therapy protocols are recommended, especially with prolonged use or higher doses.

Overall, LGD4 shows promise as a potential therapeutic agent for muscle-related disorders, as well as a performance-enhancing compound. However, further research is needed to establish its long-term safety, efficacy, and potential interactions in humans. Consulting with healthcare professionals is essential before using any new compound to ensure its suitability and safety for individual circumstances.

WARNING: This product is intended for research purposes only. The research chemical designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

  1. Pitsinos EN, Angelis YS, Petrou M. Structure revision and chemical synthesis of ligandrol’s main bishydroxylated long-term metabolic marker. Org Biomol Chem. 2022;20(46):9112-9116. Published 2022 Nov 30. doi:10.1039/d2ob01907h
  2. Cardaci TD, Machek SB, Wilburn DT, et al. LGD-4033 and MK-677 use impacts body composition, circulating biomarkers, and skeletal muscle androgenic hormone and receptor content: A case report. Exp Physiol. 2022;107(12):1467-1476. doi:10.1113/EP090741
  3. Dalton JT, Taylor RP, Mohler ML, Steiner MS. Selective androgen receptor modulators for the prevention and treatment of muscle wasting associated with cancer. Curr Opin Support Palliat Care. 2013;7(4):345-351. doi:10.1097/SPC.0000000000000015
  4. Hoffmann DB, Derout C, Müller-Reiter M, et al. Effects of ligandrol as a selective androgen receptor modulator in a rat model for osteoporosis [published online ahead of print, 2023 Jul 6]. J Bone Miner Metab. 2023;10.1007/s00774-023-01453-8. doi:10.1007/s00774-023-01453-8
  5. Basaria S, Collins L, Dillon EL, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci. 2013;68(1):87-95. doi:10.1093/gerona/gls078
  6. Cardaci TD, Machek SB, Wilburn DT, et al. LGD-4033 and MK-677 use impacts body composition, circulating biomarkers, and skeletal muscle androgenic hormone and receptor content: A case report. Exp Physiol. 2022;107(12):1467-1476. doi:10.1113/EP090741

 

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