Description
We are proud to sell MK-677 in a bottle of 60 capsules with 20mg per capsule.
MK-677, also known as Ibutamoren, is a selective ghrelin receptor agonist that has gained significant attention for its potential benefits in promoting growth hormone (GH) secretion and increasing insulin-like growth factor 1 (IGF-1) levels. Extensive research has been conducted to understand its mechanism of action, both in vitro and in vivo. This article aims to delve into the intricate workings of MK-677, exploring its therapeutic potential and shedding light on the experimental studies conducted to unravel its biological effects.
Structure and Properties of MK-677 [1]:
MK-677 is a non-peptide compound that binds to and activates the ghrelin receptor, known as the growth hormone secretagogue receptor (GHSR). MK-677 has a similar structure to ghrelin, a hormone that stimulates GH release and plays a role in appetite regulation.
Mechanism of Action:
MK-677 exerts its effects by binding to and activating the GHSR. Activation of GHSR leads to the stimulation of the GH-IGF-1 axis and the subsequent cascade of events. Here are the key mechanisms through which MK-677 operates:
a. Increased Growth Hormone Secretion [2]:
MK-677 stimulates the release of GH from the pituitary gland by activating the GHSR. This activation leads to the increased production and release of GH into the bloodstream. GH plays a vital role in growth, metabolism, and tissue repair.
b. Stimulation of Insulin-Like Growth Factor 1 (IGF-1) Production:
GH, released in response to MK-677, acts on the liver and other tissues to promote the production of IGF-1. IGF-1 is a key mediator of GH’s growth-promoting effects. It stimulates cell growth, protein synthesis, and tissue regeneration [3].
c. Promotion of Appetite:
MK-677 has been shown to increase appetite, potentially through its activation of the ghrelin receptor. Ghrelin, known as the “hunger hormone,” stimulates appetite and regulates energy balance. MK-677’s interaction with the ghrelin receptor may contribute to its appetite-stimulating effects [4].
In Vitro Studies:
In vitro studies have provided valuable insights into the cellular mechanisms of MK-677. Researchers have utilized cell cultures, including pituitary cells and liver cells, to investigate its effects. These studies have highlighted the following findings:
a. GH Secretion:
In vitro studies have demonstrated that MK-677 promotes GH secretion from pituitary cells. MK-677 activates the GHSR on pituitary cells, leading to increased GH synthesis and release. These findings support its role as a growth hormone secretagogue.
b. IGF-1 Production:
MK-677 has been shown to stimulate the production of IGF-1 in liver cells. Activation of the GH-IGF-1 axis by MK-677 leads to increased IGF-1 synthesis and secretion. These findings suggest its potential application in promoting tissue growth and repair.
In Vivo Studies:
In vivo studies have provided further evidence of MK-677’s potential benefits. These studies have been conducted in animal models and human subjects. Here are some key findings from in vivo studies:
a. Increased Growth Hormone Levels:
Animal studies have demonstrated that MK-677 administration leads to increased circulating GH levels. MK-677 stimulates the release of GH from the pituitary gland, resulting in elevated GH levels. These findings support its role as a growth hormone secretagogue.
b. Enhanced Muscle Mass and Strength:
Animal and human studies have indicated that MK-677 administration leads to increased muscle mass and improved muscle strength. MK-677’s ability to stimulate GH secretion and enhance IGF-1 levels contributes to muscle protein synthesis, muscle growth, and muscle strength improvement. These effects suggest its potential application in muscle wasting conditions and age-related muscle loss [5].
c. Bone Density Improvement:
MK-677 has been shown to have positive effects on bone density. Animal studies have demonstrated that MK-677 administration leads to increased bone mineral density and bone strength. These findings suggest its potential application in conditions such as osteoporosis and bone fractures [6].
d. Metabolic Effects:
MK-677 has shown efficacy in improving metabolic parameters. Animal studies have indicated that MK-677 administration can increase energy expenditure, improve insulin sensitivity, and enhance lipid metabolism. These effects contribute to its potential application in metabolic disorders such as obesity and diabetes [7].
Clinical Applications and Future Perspectives:
The therapeutic potential of MK-677 has garnered interest, particularly in the fields of muscle wasting disorders, age-related muscle loss, and metabolic disorders. While research is ongoing, preliminary clinical studies have shown promising results. MK-677 has demonstrated efficacy in promoting muscle growth, improving muscle strength, and potentially addressing metabolic disorders.
In the future, further investigations are needed to determine the optimal dosage, treatment duration, and potential long-term effects of MK-677. Clinical trials are underway, aiming to evaluate its safety and efficacy in larger patient populations. Moreover, research is focused on exploring potential applications of MK-677 in conditions such as muscle wasting diseases, age-related muscle loss, and metabolic disorders.
Conclusion:
MK-677, through its activation of the ghrelin receptor, plays a crucial role in the stimulation of GH secretion and the subsequent cascade of events in the GH-IGF-1 axis. In vitro and in vivo studies have elucidated its ability to increase GH secretion, enhance IGF-1 production, promote muscle growth, improve muscle strength, and potentially address metabolic disorders. These findings provide a foundation for the potential applications of MK-677 in muscle wasting disorders, age-related muscle loss, and metabolic disorders. As research continues, MK-677 may emerge as a valuable tool in promoting muscle growth, improving metabolic health, and addressing age-related muscle decline. However, it is essential to recognize the need for further research to fully understand its mechanisms of action, evaluate its efficacy, and assess its long-term safety.
WARNING: This product is intended for research purposes only. The research chemical designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. Bodily introduction of any kind into humans or animals is strictly forbidden by law.
- Patchett AA, Nargund RP, Tata JR, et al. Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue. Proc Natl Acad Sci U S A. 1995;92(15):7001-7005. doi:10.1073/pnas.92.15.7001
- Svensson J, Boguszewski CL, Shibata F, Carlsson B, Carlsson LM, Bengtsson BA. The effect of treatment with the oral growth hormone (GH) secretagogue MK-677 on GH isoforms. Growth Horm IGF Res. 2003;13(1):1-7. doi:10.1016/s1096-6374(02)00138-7
- Lee J, Kwon A, Chae HW, Lee WJ, Kim TH, Kim HS. Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats. Yonsei Med J. 2018;59(10):1174-1180. doi:10.3349/ymj.2018.59.10.1174
- Baldanzi G, Filigheddu N, Cutrupi S, et al. Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J Cell Biol. 2002;159(6):1029-1037. doi:10.1083/jcb.200207165
- Cardaci TD, Machek SB, Wilburn DT, et al. LGD-4033 and MK-677 use impacts body composition, circulating biomarkers, and skeletal muscle androgenic hormone and receptor content: A case report. Exp Physiol. 2022;107(12):1467-1476. doi:10.1113/EP090741
- Svensson J, Ohlsson C, Jansson JO, et al. Treatment with the oral growth hormone secretagogue MK-677 increases markers of bone formation and bone resorption in obese young males. J Bone Miner Res. 1998;13(7):1158-1166. doi:10.1359/jbmr.1998.13.7.1158
- Svensson J, Ohlsson C, Jansson JO, et al. Treatment with the oral growth hormone secretagogue MK-677 increases markers of bone formation and bone resorption in obese young males. J Bone Miner Res. 1998;13(7):1158-1166. doi:10.1359/jbmr.1998.13.7.1158
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